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KMID : 0882420170920010103
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Korean Journal of Medicine
2017 Volume.92 No. 1 p.103 ~ p.107
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Co-existent Mixed Connective Tissue Disease and Papillary Thyroid Cancer in a Patient with Primary Biliary Cirrhosis
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Koo Dong-Wan
Lee Seong-Geun
Park Eun-Kyoung
Park Ji-Hye
Lee Kyu-Min
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Abstract
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A 40-year-old female previously diagnosed with primary biliary cirrhosis was referred to the hospital complaining of muscle weakness, arthralgia, Raynaud’s phenomenon, and thick skin. After work-up, she was diagnosed with both mixed connective tissue disease (MCTD) and papillary thyroid cancer (PTC), based on the Alarcon-Segovia criteria and pathological examination, respectively. High-dose glucocorticoid and azathioprine were introduced to treat active myositis of MCTD, and total thyroidectomy was performed to treat PTC. This report highlights the possible association between MCTD and thyroid cancer, and suggests that MCTD is associated with PTC, similar to other autoimmune diseases including Sjogren’s syndrome, systemic sclerosis, and systemic lupus erythematosus.
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KEYWORD
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Mixed connective tissue disease, Thyroid neoplasms, Liver cirrhosis, Biliary, Myositis
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